By an Act of Parliament of the Republic of Ghana, CSIR Act 521 of 1996, the Council for Scientific and Industrial Research, CSIR, Ghana’s main R&D Organisation was re-established with a new mandate to conduct market-oriented, demand-driven research and also to commercialise the research results & technologies developed. The CSIR was tasked to recover three-quarters of its annual operating expenses through contract research and services. Over five years of implementation, what are the experiences? This paper looks at the implementation process, the attitude of research scientists towards the change and the impact of the commercialisation process on the socio-economic development of Ghana. The constraint of commercialisation including inadequate intellectual property laws is discussed. The intellectual property rights protection from the perspective of a developing country is also discussed. Intellectual property-related laws cannot remain static in a world where economic development is becoming increasingly technology-based. Intellectual property laws are going to be more stringent and stricter in the days to come, offering more opportunities and challenges.