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Nature Research, Nature Medicine, 8(21), p. 846-853, 2015

DOI: 10.1038/nm.3915

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Toward understanding and exploiting tumor heterogeneity

Journal article published in 2015 by Ash A. Alizadeh ORCID, Victoria Aranda, Alberto Bardelli, Cedric Blanpain, Christoph Bock ORCID, Christine Borowski, Carlos Caldas, Andrea Califano, Michael Doherty, Markus Elsner, Manel Esteller, Rebecca Fitzgerald, Jan O. Korbel, Peter Lichter, Christopher E. Mason and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here.