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Wiley, European Journal of Organic Chemistry, 10(1998), p. 2119-2125, 1998

DOI: 10.1002/(sici)1099-0690(199810)1998:10<2119::aid-ejoc2119>3.0.co;2-k

Wiley, European Journal of Organic Chemistry, 10(1998), p. 2119-2125

DOI: 10.1002/(sici)1099-0690(199810)1998:10<2119::aid-ejoc2119>3.3.co;2-b

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A Facile Solid‐Phase Synthesis of Oligonucleotides Containing a 3′− 3′ Phosphodiester Bond for Alternate Strand Triple‐Helix Formation

Journal article published in 1998 by Lorenzo De Napoli, Giovanni Di Fabio, Anna Messere, Daniela Montesarchio, Gennaro Piccialli ORCID, Michela Varra
This paper is available in a repository.
This paper is available in a repository.

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Abstract

An improved protocol for the synthesis of oligonucleotides containing a 3′− 3′ phosphodiester linkage, for use in an alternate strand triple-helix formation approach, is reported. Three 16-mers and one 24-mer have been efficiently synthesized and the corresponding triplexes have been analyzed by thermal denaturation experiments and CD spectroscopy