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Elsevier, Schizophrenia Research, 1-3(157), p. 149-156, 2014

DOI: 10.1016/j.schres.2014.04.032

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Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia

Journal article published in 2014 by Chenyao Wang, Takayoshi Koide, Hiroki Kimura, Shohko Kunimoto, Akira Yoshimi, Yukako Nakamura, Itaru Kushima, Masahiro Banno ORCID, Naoko Kawano, Yuto Takasaki, Jingrui Xing, Yukihiro Noda, Akihiro Mouri, Branko Aleksic ORCID, Masashi Ikeda and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candidate for mediating schizophrenia pathogenesis. Here, we investigated rare, deleterious single nucleotide variants (SNVs) as well as small insertions and deletions (INDELs) in FBXO45 that may contribute to schizophrenia susceptibility.