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American Chemical Society, Chemical Reviews, 9(115), p. 3518-3563, 2015

DOI: 10.1021/cr500638n

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Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

Journal article published in 2015 by Jessica Nasica-Labouze, Phuong H. Nguyen, Fabio Sterpone, Olivia Berthoumieu, Nicolae-Viorel Buchete ORCID, Sébastien Coté, Alfonso De Simone, Andrew James Doig, Alessandro Laio, Mai Suan Li, Peter Faller, Suan Li Mai, Simone Melchionna, Angel Garcia, Normand Mousseau and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Researchers present an in-depth review on the contribution of biophysical and biochemical studies and computer simulations to characterize the molecular structures of Aβ1-40/1-42 monomers, oligomers, protofibrils, and amyloid fibrils in aqueous solution. They focus their current knowledge of the Aβ1-40/1-42 nucleus and the structures and dynamics of Aβ1-40/1-42 oligomers in proximity of or at the membrane. They also the available information regarding the interactions of Aβ monomers and oligomers with ion metals, cellular partners, and potential inhibitors.