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Nature Research, Nature Neuroscience, 12(18), p. 1707-1712, 2015

DOI: 10.1038/nn.4156

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The PsychENCODE project

Journal article published in 2015 by Schahram Akbarian, Chunyu Liu, James A. Knowles, Flora M. Vaccarino ORCID, Peggy J. Farnham ORCID, Gregory E. Crawford, Andrew E. Jaffe, Dalila Pinto, Stella Dracheva, Daniel H. Geschwind, Jonathan Mill, Angus C. Nairn, Alexej Abyzov, Sirisha Pochareddy, Shyam Prabhakar and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understanding precisely how these variants contribute to disease will require a deeper appreciation for the mechanisms of gene regulation in the developing and adult human brain. The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type-specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems. We are beginning with a focus on autism spectrum disorder, bipolar disorder and schizophrenia, and expect that this knowledge will apply to a wide variety of psychiatric disorders. This paper outlines the motivation and design of PsychENCODE.