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Nature Research, Nature Genetics, 12(47), p. 1449-1456, 2015

DOI: 10.1038/ng.3424

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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Journal article published in 2015 by Johan C. de Jongste, Maria Pino Yanes, Lavinia Paternoster ORCID, Marie Standl, David P. Strachan, Johannes Waage, Herman T. den Dekker, Jacob P. Thyssen, Feng Li Xiao, Patrick M. A. Sleiman, Cheng-Jian Xu, Birgit Kalb, Chao Tian, Maria Pino-Yanes, Melanie Hotze and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.