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Springer, Systems and Synthetic Biology, 2(8), p. 169-171, 2014

DOI: 10.1007/s11693-014-9148-4

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Identifying pseudogenes from hypothetical proteins for making synthetic proteins

Journal article published in 2014 by P. R. Shidhi, Achuthsankar S. Nair, Prashanth Suravajhala ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Nature selected certain regions of the genome for encoding proteins. Most of the sequences were used to encode only RNA. What happened to the remaining sections of the genome? It is possible that some sequences were retired and retained as non-functional entities called pseudogenes. Though several evolutionary prospects with functional endpoints exist, we looked at the possibility of hypothetical proteins correlating with the emergence of pseudogenes and potential of such genes to make novel synthetic molecules. In this commentary, we consider two key aspects: (1) does any correlation exist between hypothetical proteins and pseudogenes and (2)—can we make novel and functional proteins from pseudogenes?