Bringing together analysis across different sectors, we review the implementation and achievements of the MDGs to date to identify cross cutting strengths and weaknesses as a basis for considering how they might be developed or replaced after 2015. Working from this and a definition of development as a dynamic process involving sustainable and equitable access to improved wellbeing, five interwoven guiding principles are proposed for a post 2015 development project: holism, equity, sustainability, ownership, and global obligation. These principles and their possible implications in application are expanded and explored. The paper concludes with an illustrative discussion of how these principles might be applied in the health sector.