Published in
Nature Research, Nature Structural and Molecular Biology, 4(15), p. 419-421, 2008
DOI: 10.1038/nsmb.1400
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The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif
Journal article published in 2008 by
Shengjiang Tu 
,
Yu-Ching Teng,
Chunhua Yuan,
Ying-Ta Wu,
Meng-Yu Chan,
An-Ning Cheng,
Po-Hsun Lin,
Li-Jung Juan,
Ming-Daw Tsai
,
Yu-Ching Teng,
Chunhua Yuan,
Ying-Ta Wu,
Meng-Yu Chan,
An-Ning Cheng,
Po-Hsun Lin,
Li-Jung Juan,
Ming-Daw Tsai
This paper is made freely available by the publisher.
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Abstract
The histone H3 lysine 4 demethylase RBP2 contains a DNA binding domain, the AT-rich interaction domain (ARID). We solved the structure of ARID by NMR, identified its DNA binding motif (CCGCCC) and characterized the binding contacts. Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.