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Royal Society of Chemistry, Soft Matter, 5(6), p. 862

DOI: 10.1039/b915800f

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Neutron reflectometry of supported hybrid bilayers with inserted peptide

Journal article published in 2010 by Matthew B. Smith, Duncan J. McGillivray, Jan Genzer, Mathias Lösche ORCID, Peter K. Kilpatrick
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The insertion of a synthetic amphiphilic, α-helical peptide into a supported hybrid bilayer membrane (HBM) was studied by neutron reflectometry to elucidate the resulting nanostructure. The HBM consisted of a self-assembled monolayer of perdeuterated octadecanethiol on gold and an overlying leaflet of acyl-deuterated phosphatidylcholine (d-DMPC). Using contrast variation, several reflectivity spectra were recorded for each step of film fabrication, and simultaneously modeled. This analysis indicated that peptide insertion into the DMPC lipid leaflet is the likeliest mode of incorporation.