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j biomater tissue eng, 11(4), p. 868-874

DOI: 10.1166/jbt.2014.1263

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Biodegradable Metal Stents: A Focused Review on Materials and Clinical Studies

Journal article published in 2014 by Agung Purnama, Hendra Hermawan, Diego Mantovani
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Coronary artery disease (CAD) is the most common type of heart disease caused by plaque building up along the inner walls of coronary arteries which narrows the lumen and reduces blood flow. Stenting is the current standard procedure to treat the disease by opening the narrowed arteries and restoring the blood flow. Stenting has been revolutionary evolved from the use of bare metal stents made of corrosion resistant alloys to the incorporation of anti-proliferative drugs in the drug eluting stents. Despite the advantages and limitation of the current stent technology, the permanent presence of stents in the arteries is questionable, especially for some applications, including pediatric, in presence of collateral arteries, and others. Biodegradable stents, designed to support the arterial wall and disappear after its remodelling, therefore constitute an interesting choice, possibly representing the next revolutionary treatment of CAD. Magnesium, iron, zinc and their alloys are among metals have been proposed as biodegradable stent materials. These metals are designed to degrade in vivo through corrosion process without posing toxicity problems to the body and called as biodegradable metals. Stents made of magnesium and its alloys have been the most studied, developed and reached clinical trials in humans, followed by those made of iron which reached in vivo studies in animals. Meanwhile, zinc is just recently proposed with only few studies have been reported. This papers presents a focused review on the development of biodegradable metals for stents.