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Elsevier, NeuroImage, 3(38), p. 501-510, 2007

DOI: 10.1016/j.neuroimage.2007.06.043

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Mixed-effect statistics for group analysis in fMRI: A nonparametric maximum likelihood approach

Journal article published in 2007 by Alexis Roche, Sébastien Mériaux ORCID, Merlin Keller, Bertrand Thirion
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

This technical note describes a collection of test statistics accounting for estimation uncertainties at the within-subject level, that can be used as alternatives to the standard t statistic in one-sample random-effect analyses, i.e. when testing the mean effect of a population. We build such test statistics by estimating the across-subject distribution of the effects using maximum likelihood under a nonparametric mixed-effect model. For inference purposes, the statistics are calibrated using permutation tests to achieve exact false positive control under a symmetry assumption regarding the across-subject distribution. The new tests are implemented in a freely available toolbox for SPM called Distance.