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Elsevier, Prostaglandins and Other Lipid Mediators, (107), p. 95-102

DOI: 10.1016/j.prostaglandins.2013.04.003

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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.

Journal article published in 2013 by Jean-Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori ORCID, Cinzia Signorini, Claudio De Felice ORCID, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean-Yves Le Guennec, Camille Oger, Thierry Durand
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.