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American Chemical Society, ACS Chemical Biology, 3(1), p. 132-134, 2006

DOI: 10.1021/cb600138j

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Micromanagement: A Role for MicroRNAs in mRNA Stability

Journal article published in 2006 by Sarah F. Roush, Frank J. Slack ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a post-transcriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.