American Chemical Society, ACS Chemical Biology, 3(1), p. 132-134, 2006
DOI: 10.1021/cb600138j
Full text: Unavailable
Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a post-transcriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.