Suzuki cross-coupling reaction was successfully carried out in ethanol utilizing a palladium colloidal solution stabilized by polyvinylpyrrolidone (PVP). High isolated yields (75–97%) to biaryls were obtained using different bases, aryl halides, and aryl boronic acids with a small loading of the palladium catalyst. Pd(0)–PVP nanoparticles with 3–6nm of medium diameter were prepared from Pd(OAc)2 in the presence of the stabilizer PVP using methanol as the reducing agent.