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Royal Society of Chemistry, Nanoscale, 17(7), p. 7885-7895

DOI: 10.1039/c4nr07335e

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Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Journal article published in 2015 by Hui Wang, Guixin Cao, Zheng Gai ORCID, Kunlun Hong ORCID, Probal Banerjee, Shuiqin Zhou
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The paper reports a type of multifunctional hybrid nanoparticles (NPs) composed of gold nanocrystals coated on and/or embedded in the magnetite-fluorescent porous carbon core-shell NP template (Fe3O4@PC-CDs-Au) for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy. The synthesis of the Fe3O4@PC-CDs-Au NPs involves the first preparation of the core-shell template NPs with magnetite nanocrystals clustered in core and fluorescent carbon dots (CDs) embedded in the porous carbon shell, followed by an in-situ reduction of silver ions (Ag+) loaded in the porous carbon shell and a subsequent replacement of Ag NPs with Au NPs through a galvanic replacement reaction using HAuCl4 as precursor. The Fe3O4@PC-CDs-Au NPs can enter into the intracellular region and light up the mouse melanoma B16F10 cells in multicolor modal. The porous carbon shell anchored with hydrophilic hydroxyl/carboxyl groups endow the Fe3O4@PC-CDs-Au NPs with an excellent stability in aqueous phase and a high loading capacity (719 mg g−1) for the anti-cancer drug of doxorubicin (DOX). The superparamagnetic Fe3O4@PC-CDs-Au NPs with a saturation magnetization of 23.26 emu/g produce a localized heat under an alternating magnetic field, which triggers the release of the loaded drug. The combined photothermal effects of Au nanocrystals and CDs on/in the carbon shell cannot only regulate the release rate of the loaded drug, but also efficiently kill tumor cells under the NIR irradiation. Benefited from their excellent optical properties, magnetic field and NIR light responsive drug release, and enhanced photothermal effect, such nanostructured Fe3O4@PC-CDs-Au hybrid NPs provide a great promise for the simultaneous imaging diagnostics and high efficacy therapy.