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Nature Research, Nature Genetics, 12(41), p. 1335-1340, 2009

DOI: 10.1038/ng.489

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Common variants at five new loci associated with early-onset inflammatory bowel disease

Journal article published in 2009 by Martine de Vos, Marcin Imielinski, Robert N. Baldassano, Anne Griffiths, Richard K. Russell, Gary Silber, Vito Annese, Marla Dubinsky, Iwona Wrobel, Subra Kugathasan, Antonio Quiros, Jonathan P. Bradfield, Jeffrey C. Barrett, Patrick Sleiman, Sarah Hansoul and other authors.
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This paper is available in a repository.

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Abstract

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD1. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.