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American Chemical Society, Journal of The American Society for Mass Spectrometry, 3(17), p. 376-383, 2006

DOI: 10.1016/j.jasms.2005.11.017

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Dominulin A and B: Two new antibacterial peptides identified on the cuticle and in the venom of the social paper waspPolistes dominulususing MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap

Journal article published in 2006 by Stefano Turillazzi, Guido Mastrobuoni, Francesca R. Dani, Gloriano Moneti, Giuseppe Pieraccini, Giancarlo la Marca ORCID, Gianluca Bartolucci, Brunella Perito, Duccio Lambardi, Vanni Cavallini, Leonardo Dapporto
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Two new antibacterial peptides, denominated as Dominulin A and B, have been found on the cuticle and in the venom of females of the social paper wasp Polistes dominulus. The amino acidic sequence of the two peptides, determined by mass spectrometry, is INWKKIAE VGGKIL SSL for Dominulin A (MW = 1854 Da) and INWKKIAEIGKQVL SAL (MW = 1909 Da) for Dominulin B. Their presence on the cuticle was confirmed using MALDI-TOF by means of micro-extractions and direct analyses on body parts. The presence in the venom and the primary structure of the dominulins suggest their classification in the mastoparans, a class of peptides found in the venom of other Aculeate hymenoptera. Their antimicrobial action against Gram+ and Gram- bacteria fits in the range of the best natural antimicrobial peptides. Dominulins can represent an important defense of the colony of Polistes dominulus against microbial pathogens.