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ACS=acute coronary syndromes; ADP=adenosine diphosphate; CI=confidence interval; CV=cardiovascular; GI=gastrointestinal; HR=hazard ratio; H2RA=histamine H2 receptor antagonist; MI=myocardial infarction; NNH=number-needed-to-harm; NSAID=nonsteroidal anti-inflammatory drug; OR=odds ratio; PCI=percutaneous coronary intervention; PPI=proton pump inhibitor; RCT=randomized clinical trial; RR=relative risk; VASP=vasodilator-stimulated phosphoprotein