This model discusses the mechanism of microneedle patch. It shows how this invention could deal with the immune system, benefits, and different methods to overcome challenges. The studies presented in this paper were done to improve previous drug delivery applications by comparing and avoiding their disadvantages. The studies show that patch mechanism, material of various fabrication types, the particulate dosage, site-specific are fundamental factors for effective drug delivery patch, and the acceptability of using the patch. The limitations were how to go through intradermal layer and reach the target shortly and the cost of the patch. This initial paper indicates that microneedle patches for self-administrated against different diseases are applicable and lead to improve the drug delivery field. This paper proves that drug delivery system is complicated and finds an easy and effective method is not impossible and could help people in developing country and saving time.