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Wiley, Cochrane Library, 2(2018), 2018

DOI: 10.1002/14651858.cd008806.pub3

Wiley, Cochrane Library, 2013

DOI: 10.1002/14651858.cd008806.pub2

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Osmotic therapies added to antibiotics for acute bacterial meningitis

Journal article published in 2013 by Emma Cb Wall, Katherine Mb Ajdukiewicz, Hanna Bergman, Robert S. Heyderman, Paul Garner ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Every day children and adults throughout the world die from acute community-acquired bacterial meningitis, particularly in low-income countries. Survivors are at risk of deafness, epilepsy and neurological disabilities. Osmotic therapies have been proposed as an adjunct to improve mortality and morbidity from bacterial meningitis. The theory is that they will attract extra-vascular fluid by osmosis and thus reduce cerebral oedema by moving excess water from the brain into the blood. The intention is to thus reduce death and improve neurological outcomes.