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Nature Research, Nature Medicine, 12(11), p. 1295-1298, 2005

DOI: 10.1038/nm1330

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Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

Journal article published in 2005 by Gang Chen, Hua Qian, Thomas Starzl, Hongtao Sun, Bertha Garcia, Ximo Wang, Yishai Wise, Yuanqing Liu, Ying Xiang, Laura Copeman, Weihua Liu, Anthony Jevnikar ORCID, William Wall, David K. C. Cooper, Cooper Dkc and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.