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Springer, Journal of Membrane Biology, 4(248), p. 611-640, 2015

DOI: 10.1007/s00232-015-9802-0

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Membrane Protein Structure, Function, and Dynamics: A Perspective from Experiments and Theory

Journal article published in 2015 by Zoe Cournia, TobyW Allen, Ioan Andricioaei, Bruno Antonny, Daniel Baum, Grace Brannigan, Nicolae-Viorel Buchete ORCID, JasonT Deckman, Lucie Delemotte ORCID, Coral del Val, Ran Friedman, Paraskevi Gkeka, Hans-Christian Hege, Jérôme Hénin, MarinaA Kasimova and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.