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Wiley, Angewandte Chemie International Edition, 14(51), p. 3340-3344, 2012

DOI: 10.1002/anie.201108015

Wiley, Angewandte Chemie, 14(124), p. 3396-3400, 2012

DOI: 10.1002/ange.201108015

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The Crystal Structure of Human α2-Macroglobulin Reveals a Unique Molecular Cage

Journal article published in 2012 by Aniebrys Marrero, F. Xavier Gomis Rüth, Stephane Duquerroy, Stefano Trapani, Theodoros Goulas, Tibisay Guevara, Gregers R. Andersen, Jorge Navaza, Lars Sottrup-Jensen, F. Xavier Gomis-Rüth
This paper is available in a repository.
This paper is available in a repository.

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Abstract

I'm your Venus: The crystal structure of the human methylamine-induced form of α(2) -macroglobulin (α(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2) M.