Published in

Elsevier, Current Opinion in Neurobiology, 5(21), p. 679-684

DOI: 10.1016/j.conb.2011.05.015

Links

Tools

Export citation

Search in Google Scholar

Modeling developmental patterns of spontaneous activity

Journal article published in 2011 by Julijana Gjorgjieva ORCID, Stephen J. Eglen ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Orange circle
Postprint: archiving restricted
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO

Abstract

Spontaneous activity is found in many regions of the developing nervous system; such activity is thought to be instructive for guiding developmental processes. In particular, the developing retina generates correlated patterns of activity known as retinal waves. We review the main theoretical models that have been developed to study the mechanisms for generation and propagation of retinal waves. Much of the progress in this field has been due to the close interaction between experimentalists and theorists in analyzing and modeling spontaneous activity. We conclude by describing spontaneous activity models in other systems and suggestions for future modeling work.