Synthesis of 5,6-Spiroethers and Evaluation of their Affinities for the Bacterial A Site
Journal article published in 2011 by
Ioannis A. Katsoulis,
Georgia Kythreoti,
Athanasios Papakyriakou 
,
Konstantina Koltsida,
Panoula Anastasopoulou,
Christos I. Stathakis,
Ioannis Mavridis,
Thomas Cottin,
Emmanuel Saridakis,
Dionisios Vourloumis
,
Konstantina Koltsida,
Panoula Anastasopoulou,
Christos I. Stathakis,
Ioannis Mavridis,
Thomas Cottin,
Emmanuel Saridakis,
Dionisios Vourloumis
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low-nM fluorescence-based activity are presented.