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Royal Society of Chemistry, RSC Advances, 3(4), p. 1204-1211

DOI: 10.1039/c3ra45982a

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Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

Journal article published in 2014 by Martyn J. Earle, Marco Noè ORCID, Alvise Perosa ORCID, Kenneth R. Seddon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

An improved synthesis of tadalafil, a drug for the treatment of male erectile dysfunction, involves the use of safer solvents and reagents as well as a reduced number of steps