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2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

DOI: 10.1109/iembs.2007.4353884

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SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis.

Journal article published in 2007 by S. Randall Thomas, S. Randall Thomas, Enas Abdulhay, Pierre Baconnier, Julie Fontecave, Jean-Pierre Françoise, Francois Guillaud, Patrick Hannaert, Alfredo Hernandez, Virginie Le Rolle ORCID, Virginie Le Rolle, Pierre Maziere, Fariza Tahi, Farida Zehraoui
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions". The project uses state-of-the-art multi-scale simulation methods. The basic core model will give succinct input-output (reduced-dimension) descriptions of all relevant organ systems and regulatory processes, and it will be modular, multi-resolution, and extensible, in the sense that detailed submodules of any process(es) can be "plugged-in" to the basic model in order to explore, eg. system-level implications of local perturbations. The goal is to keep the basic core model compact enough to insure fast execution time (in view of eventual use in the clinic) and yet to allow elaborate detailed modules of target tissues or organs in order to focus on the problem area while maintaining the system-level regulatory compensations.