Published in

Oxford University Press (OUP), International Journal of Epidemiology, 4(44), p. 1388-1396

DOI: 10.1093/ije/dyu277

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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The DNA methylation-based ‘epigenetic clock’ correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.