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Public Library of Science, PLoS ONE, 9(10), p. e0138863, 2015

DOI: 10.1371/journal.pone.0138863

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Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency

Journal article published in 2015 by Sebastian Heinzel, Florian G. Metzger, Ann-Christine Ehlis, Robert Korell, Ahmed Alboji, Florian B. Haeussinger, Isabel Wurster, Kathrin Brockmann, Ulrike Suenkel, Gerhard W. Eschweiler, Walter Maetzler, Daniela Berg, Andreas J. Fallgatter
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aging processes and several vascular burden factors have been shown to increase the risk of dementia including Alzheimer's disease. While pathological alterations in dementia precede diagnosis by many years, reorganization of brain processing might temporarily delay cognitive decline. We hypothesized that in healthy elderly individuals both age-related neural and vascular factors known to be related to the development of dementia impact functional cortical hemodynamics during increased cognitive demands.