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Elsevier, EBioMedicine, 8(2), p. 909-918, 2015

DOI: 10.1016/j.ebiom.2015.06.012

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Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders

Journal article published in 2015 by Baohu Ji, Kerin K. Higa, John R. Kelsoe, Xianjin Zhou
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X syndrome (XXX). Over-dosage of some X-linked escapee genes was suggested to cause psychiatric disorders. However, relevance of these rare genetic diseases to the pathogenesis of psychiatric disorders in the general population of psychiatric patients is unknown.