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Nature Research, Nature Genetics, 4(47), p. 381-386, 2015

DOI: 10.1038/ng.3245

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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Journal article published in 2015 by Suna Onengut-Gumuscu, Chen Wm, Aaron R. Quinlan, Cooper Nj, Josyf C. Mychaleckyj, Mychaleckyj Jc, Michal Szpak, Bonnie Jk, Ellen Schofield, Neil M. Walker, Luke D. Ward, Helen Stevens, Fortune Md, Walker Nm, Anshul Kundaje and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions1,2 (www.T1DBase.org) revealing major pathways contributing to risk3, with some loci shared across immune disorders4–6. In order to make genetic comparisons across autoimmune disorders as informative as possible a dense genotyping array, the ImmunoChip, was developed, from which four novel T1D regions were identified (P