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American Society of Hematology, Blood, 14(124), p. 2173-2183, 2014

DOI: 10.1182/blood-2014-05-573543

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Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key PointsWhen activated and in platelet storage bags, platelets release respiratory-competent mitochondria, a recognized damage-associated molecular pattern. Mitochondria, descendant of Rickettsia prowazekii, serve as substrate for bactericidal sPLA2-IIA to promote inflammation.