American Society of Hematology, Blood, 14(124), p. 2173-2183, 2014
DOI: 10.1182/blood-2014-05-573543
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Key PointsWhen activated and in platelet storage bags, platelets release respiratory-competent mitochondria, a recognized damage-associated molecular pattern. Mitochondria, descendant of Rickettsia prowazekii, serve as substrate for bactericidal sPLA2-IIA to promote inflammation.