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Nature Research, Nature Genetics, 8(43), p. 753-760

DOI: 10.1038/ng.866



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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Journal article published in 2011 by Tuomas O. Kilpeläinen, Mc Carola Zillikens, Kilpeläinen To, Zillikens Mc, Alena Stančáková, A. Stanč;ákova, Francis M. Finucane, Finucane Fm, Janina S. Ried, Ried Js, Claudia Langenberg, Weihua Zhang, Jacques S. Beckmann ORCID, Beckmann Js, Jian’an Luan and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Genome-wide association studies have identified 32 loci associated with body mass index (BMI), a measure that does not allow distinguishing lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals, and followed up the 14 most significant (P