Wiley, FEBS Letters, 21(586), p. 3819-3824, 2012
DOI: 10.1016/j.febslet.2012.09.027
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► Histamine is covalently attached to protein-integrated glutamine residues. ► Transglutaminase II (TGM2) is catalyzing protein histaminylation in P815 mast cells. ► Histaminylation of a catalytic glutamine activates G proteins Gαq, Gαo1 and Cdc42. ► Histaminylation is a novel posttranslational modification belonging to the class of protein monoaminylations.