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Nature Research (part of Springer Nature), Nature Communications, (7), p. 10023

DOI: 10.1038/ncomms10023

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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Journal article published in 2016 by Peter J. van der Most, Yvonne T. van der Schouw ORCID, Pio d’Adamo, Pio d\textquoterightAdamo, Cristian Pattaro ORCID, Pim van der Harst, Wiek H. van Gilst, Alexander Teumer ORCID, Mathias Gorski, Audrey Y. Chu, Man Li, Y. Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways. ; Study-specific acknowledgements and funding sources for participating studies are reported in Supplementary Note. Zebrafish work was supported by NIH R01DK090311 and R24OD017870 to W.G. ; Peer-reviewed ; Publisher Version