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Elsevier, Radiotherapy & Oncology, 1(88), p. 127-134

DOI: 10.1016/j.radonc.2008.02.018

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Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging

Journal article published in 2008 by Lucy E. Kershaw ORCID, John P. Logue, Charles E. Hutchinson, Noel W. Clarke, David L. Buckley
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

BACKGROUND AND PURPOSE: To use quantitative MRI to detect changes in the vascular and MR relaxation characteristics of the prostate gland 1 year after external beam radiotherapy. MATERIALS AND METHODS: Twenty-one patients underwent MRI before and after external beam radiotherapy for prostatic adenocarcinoma. Tracer kinetics analysis was applied to data from regions of interest in prostate tumour, normal prostate peripheral zone and muscle to obtain estimates of blood flow, extravascular-extracellular volume, blood volume and capillary permeability surface area product. T(1) and T(2) were also measured in these regions. RESULTS: Significant changes (p