Published in

Nature Research, Scientific Reports, 1(3), 2013

DOI: 10.1038/srep02535

Links

Tools

Export citation

Search in Google Scholar

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Journal article published in 2013 by Eleonora Leucci, Francesca Patella, Johannes Waage, Kim Holmstrøm, Morten Lindow, Bo Porse, Sakari Kauppinen, Anders H. Lund
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.