From the view of statistical genetics, we explore four future directions in the genetics of psychiatric disorders with the overall goal of application to genomic medicine. The themes are (1) defining genomic variation, (2) response to treatment genomics, (3) genetic risk prediction and (4) data collection for individuals measured for phenotype, genotype and environment. We conclude that genotyping technology is no longer a limiting step and that full progression of applications of genomic medicine in psychiatry is dependent on the availability of suitable individual level data and will ultimately depend on integration of genomic information as part of accessible electronic health records.