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American Medical Association, Archives of Dermatology -Chicago-, 9(143)

DOI: 10.1001/archderm.143.9.1175

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Balancing the Benefits and Risks of Drug Treatment

Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

OBJECTIVE: To examine the extent to which the attributes of a treatment affect patients' choice of treatment for psoriasis and the magnitude and nature of trade-offs between risks and benefits of treatment. DESIGN: A questionnaire, including a stated-preference, discrete choice experiment, was used to elicit patients' preferences for the treatment of psoriasis. SETTING: Dermatology clinics in England. PATIENTS: A total of 126 patients with psoriasis. MAIN OUTCOME MEASURES: Preferences of patients for, and trade-offs between, the 6 attributes of time to moderate (50%) improvement, relapse, and risks of experiencing skin irritation, high blood pressure, liver damage, and skin cancer. RESULTS: The mean age of respondents was 47.6 years, and the mean duration of psoriasis was 23 years. All 6 attributes were important factors affecting choice of treatment. The results indicated that patients with psoriasis prioritized low risk of skin cancer (beta = -0.054; P