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Hindawi, Scientific World Journal, (8), p. 1088-1097

DOI: 10.1100/tsw.2008.136

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Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2AG-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer

Journal article published in 2008 by Gemma Navarro, Paulina Carriba, Jorge Gandí, Jorge Gandía, Francisci Ciruela, Vicent Casadó ORCID, Antoni Cortés, Josefa Mallol, Enric I. Canela, Carmen Lluis, Rafael Franco
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Functional interactions in signaling occur between dopamine D(2) (D(2)R) and cannabinoid CB(1) (CB(1)R) receptors, between CB(1)R and adenosine A(2)A (A(2)AR) receptors, and between D(2)R and A(2)AR. Furthermore, direct molecular interactions have been reported for the pairs CB(1)R-D(2)R, A(2)AR- D(2)R, and CB(1)R-A(2)AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D(2)R-CB(1)R-A(2)AR hetero-oligomers in living cells.