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Wiley, Angewandte Chemie International Edition, 28(51), p. 6896-6899, 2012

DOI: 10.1002/anie.201200467

Wiley, Angewandte Chemie, 28(124), p. 7002-7005, 2012

DOI: 10.1002/ange.201200467

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Chemical probes for the recognition of cannabinoid receptors in native systems.

Journal article published in 2012 by Lidia Martín-Couce, Mar Martín-Fontecha ORCID, Oscar Palomares, Leyre Mestre, Arnau Cordomí, Miriam Hernangomez Herrero, Sara Palma, Leonardo Pardo ORCID, Carmen Guaza, María L. López-Rodríguez ORCID, Silvia Ortega-Gutiérrez ORCID
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Abstract

Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB(1) and CB(2) cannabinoid receptors (CB(1)R and CB(2)R) enable direct visualization of these receptors in native cellular systems, including neurons, microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system. ; Journal Article ; Research Support, Non-U.S. Gov't ; info:eu-repo/semantics/published