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American Chemical Society, Langmuir, 25(30), p. 7567-7575, 2014

DOI: 10.1021/la501268b

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Hydrophilic, Bright CuInS2Quantum Dots as Cd-Free Fluorescent Labels in Quantitative Immunoassay

Journal article published in 2014 by Elena S. Speranskaya, Natalia V. Beloglazova, Sofie Abé, Tangi Aubert, Philippe F. Smet ORCID, Dirk Poelman ORCID, Irina Y. Goryacheva, Sarah De Saeger, Zeger Hens
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We report on the synthesis of core-shell CuInS2/ZnS quantum dots (QDs) in organic solution, their encapsulation with a PEG-containing amphiphilic polymer, and the application of the resulting water-soluble QDs as fluorescent label in quantitative immunoassay. By optimizing the methods for core synthesis and shell growth, CuInS2/ZnS QDs were obtained with a quantum yield of 50% on average after hydrophilization. After conjugation with an aflatoxin B1-protein derivative, the obtained QDs were used as fluorescent labels in microplate immunoassay for the quantitative determination of the mycotoxin aflatoxin B1. QDs-based immunoassay showed higher sensitivity compared to enzyme-based immunoassay.