A GPS-based geodetic study at a regional scale requires the availability of a dense network that is characterized by 10 km to 30 km spacing, typically followed in a few continuous GPS stations (CGPSs) and several non-permanent GPS stations (NPSs). As short observation times do not allow adequate noise modeling, NPS data need specific processing where the main differences between NPSs and CGPSs are taken into account: primarily time-series length and antenna repositioning error. The GPS data collected in the 1999-2007 time-span from non-permanent measurement campaigns in the central Apennine area (Italy) that was recently hit by the Mw 6.3 L'Aquila earthquake (April 6, 2009) are here further analyzed to compute a reliable strain-rate field at a regional scale. Moreover, areas characterized by different kinematics are recognized, and a complete characterization of the regional-scale kinematics is attempted. These new data can be interpreted as indicators from the viewpoint of seismic risk assessment.