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Elsevier, BBA - Bioenergetics, (1837), p. e35, 2014

DOI: 10.1016/j.bbabio.2014.05.343

EMBO Press, EMBO Reports, 5(15), p. 586-591, 2014

DOI: 10.1002/embr.201337972

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UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster

Journal article published in 2014 by Caterina Da-Re, Cristiano De Pitta, Mauro A. Zordan, Zordan Ma, Giordano Teza ORCID, Fabrizio Nestola ORCID, Massimo Zeviani, Rodolfo Costa, Paolo Bernardi
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Larvae of Drosophila melanogaster reared at 23°C and switched to 14°C for 1 h are 0.5°C warmer than the surrounding medium. In keeping with dissipation of energy, respiration of Drosophila melanogaster larvae cannot be decreased by the F-ATPase inhibitor oligomycin or stimulated by protonophore. Silencing of Ucp4C conferred sensitivity of respiration to oligomycin and uncoupler, and prevented larva-to-adult progression at 15°C but not 23°C. Uncoupled respiration of larval mitochondria required palmitate, was dependent on Ucp4C and was inhibited by guanosine diphosphate. UCP4C is required for development through the prepupal stages at low temperatures and may be an uncoupling protein.