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Oxford University Press (OUP), Human Molecular Genetics, 21(21), p. 4805-4815

DOI: 10.1093/hmg/dds304



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Genome-wide meta-analysis of common variant differences between men and women

Journal article published in 2012 by A. Pio D. Adamo, Jing Hua Zhao, Adamo Pio d’Adamo, Wiek H. van Gilst, Adamo Pio d'Adamo, Joyce B. Jbj van Meurs, Eco de Geus, Martin den Heijer, Pim van der Harst, Nigel William Rayner, A. Vernon Smith, Anke Tönjes, Vesna Boraska, Ana Jeroncic, Vincenza Colonna and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P