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Public Library of Science, PLoS ONE, 11(7), p. e48818, 2012

DOI: 10.1371/journal.pone.0048818

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Mortality Associated with Diabetes and Cardiovascular Disease in Older Women

Journal article published in 2012 by David Nanchen, Nicolas Rodondi ORCID, Jacques Cornuz, Teresa Hillier, Kristine E. Ensrud, Jane A. Cauley ORCID, Douglas C. Bauer, Study of Osteoporotic Fractures Research Group
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Other ; Background Current guidelines for the prevention of cardiovascular disease (CVD) recommend diabetes as a CVD risk equivalent. However, reports that have examined the risk of diabetes in comparison to pre-existing CVD are lacking among older women. We aimed to assess whether diabetes was associated with a similar risk of total and cause-specific mortality as a history of CVD in older women. Methodology/Principal Findings We studied 9218 women aged 68 years or older enrolled in a prospective cohort study (Study of Osteoporotic Fracture) during a mean follow-up period of 11.7 years and compared all-cause, cardiovascular and coronary heart disease mortality among 4 groups: non-diabetic women with and without existing CVD, diabetic women with and without existing CVD. Mean (SD) age of the participants was 75.2 (5.3) years, 3.5% reported diabetes and 6.8% reported existing CVD. During follow-up, 5117 women died with 36% from CVD. The multivariate adjusted risk of cardiovascular mortality was increased among both non-diabetic women with CVD (hazard ratio (HR) 2.32, 95% CI: 1.97–2.74, P