Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 9(20), p. 2832-2836
DOI: 10.1016/j.bmcl.2010.03.051
Links
Tools
Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.
Journal article published in 2010 by
Ka A. Nolan,
Nolan Ka,
Ij J. Stratford,
M. P. Humphries 
,
Humphries Mp,
Ra A. Bryce,
Bryce Ra,
Stratford Ij,
Mp Humphries RA Bryce IJ Stratford Ka Nolan
,
Humphries Mp,
Ra A. Bryce,
Bryce Ra,
Stratford Ij,
Mp Humphries RA Bryce IJ Stratford Ka Nolan
This paper was not found in any repository, but could be made available legally by the author.
Full text: Unavailable
Postprint:
archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most potent inhibitor of NQO2 yet reported (IC(50)=6 nM).