AbstractSediment connectivity plays a fundamental role in sustaining ecosystem goods and services in fluvial systems, including hydropower production. Dams alter the natural processes of sediment transport by trapping sediment and reshaping downstream hydrology and geomorphology. Due to these processes' interconnected nature, dams' impacts extend in time and space beyond the dam site to the entire river system. System‐scale approaches to reduce dam impacts commonly only consider dam siting, overlooking the potential of sediment management strategies integrated into the dam operations to offer more flexible solutions for mitigation. Herein, we contribute a sediment routing model (D‐CASCADE) to assess the impacts of reservoirs and their management strategies on river sediment connectivity. D‐CASCADE is applied to the 3S river system, a tributary of the Mekong River, a hotspot of potential dams in the Lower Mekong. We analyze three dam development portfolios. The effect of reservoir management is examined by assessing daily sediment delivery with specific dam release strategies. Model results predict sediment yield to the Mekong to reduce by 31%–60%. Finally, we explore trade‐offs between hydropower generation and sediment connectivity across cascades of multiple reservoirs. Results show that repeated flushing operations during the early wet season could significantly increase sediment delivery with minimal (max 6%) hydropower losses. While poor trade‐offs between sediment and hydropower have been locked‐in in the Mekong, our results highlight the potential of including sediment connectivity models in multi‐objective decision‐making frameworks to devise integrated water and sediment management strategies that mitigate connectivity disruptions while minimizing losses in other sectors.